From childhood, Nathan Cain has been afflicted with a unique condition that renders him incapable of experiencing physical pain. This means that even severe injuries and fractures fail to register with him. To ensure his survival, he has adapted by becoming cautious and avoiding any potential trouble. However, when the love of his life is abducted during a bank robbery, Nathan's extraordinary characteristic becomes his only hope to rescue her. Thus commences the gripping narrative of "Novocaine" - an intense action film infused with thrilling elements, as weakness transforms into strength and the instinct for self-preservation drives him to fight.